Ah, at long last, another film from Hal Hartley. I first heard about this, his sequel to Henry Fool back in 2005 or so.
The plot is pretty much spaghetti, and while it demands a lot of suspension of disbelief it is easier to follow than The Girl From Monday. Most of the old characters return, though the old familiar settings of the neighbourhood, the garbage processing facility and the deli are replaced by some fairly generic European ones, as one might expect from Hal Hartley's assertion that making movies in New York is too expensive these days.
Give it a go, it's a lot of fun.